en
Industry Information
Antioxidant Properties of N-Acetylneuraminic Acid (Sialic Acid) in Facial Care
2025.03.21
N-acetylneuraminic acid (NANA, Neu5Ac, sialic acid, CAS No.: 131-48-6) is a key bioactive compound used in many fields. In this blog post, CASOV will share the effects of neural repair ingredient n-acetylneuraminic acid sialic acid in cosmeceutical and edible applications while meeting the stringent safety and purity requirements of infant formula production.
Sialic acid is known for its excellent moisture-retention properties. When incorporated into topical formulations, it binds water molecules to the skin surface, significantly improving skin hydration. Studies show that Neu5Ac enhances the skin' s natural moisturizing factor (NMF), leading to increased elasticity and a reduction in transepidermal water loss (TEWL).
One of the major contributors to skin aging is oxidative stress and glycation. Sialic acid exhibits anti-glycation properties by inhibiting the formation of advanced glycation end-products (AGEs), which cause collagen degradation and skin sagging. Moreover, sialic acid can promote the synthesis of hyaluronic acid and collagen, helping restore dermal structure and reduce the appearance of fine lines and wrinkles.
The outermost layer of the skin, the stratum corneum, relies on a balanced lipid matrix and protective glycoproteins. Sialic acid, being a component of glycoproteins and glycolipids, enhances the integrity of this barrier. When applied topically, it strengthens cellular cohesion and supports the skin' s defense against pollutants and allergens.
Sialic acid is a critical nutrient found in high concentrations in human breast milk, particularly in the form of gangliosides and glycoproteins. It is essential for brain development, synaptic plasticity, and learning in infants. Microbial fermentation-derived Sialic acid meets infant formula standards and serves as a functional additive in baby foods, effectively mimicking the benefits of human milk.
Sialic acid has shown potential prebiotic activity, promoting the growth of beneficial gut bacteria such as *Bifidobacterium* and *Lactobacillus*. By influencing the composition of intestinal flora, sialic acid supports digestive health, enhances nutrient absorption, and strengthens immune response.
In adult nutrition, dietary supplementation with sialic acid may improve memory, learning, and overall cognitive function. As part of glycoproteins and gangliosides in the central nervous system, Sialic acid contributes to neurogenesis and protects neurons from oxidative damage. These effects are especially beneficial in elderly populations or individuals facing cognitive decline.
Sialic acid produced via microbial fermentation has been assessed for safety in food and cosmetic applications. Regulatory bodies in several countries, including the U.S. FDA and EU regulatory agencies, have recognized it as safe when produced under controlled, GMP-compliant conditions. It exhibits low toxicity, is non-irritating to the skin, and poses minimal allergenic risk, making it suitable for wide consumer use.
Moreover, the fermentation-derived product avoids ethical concerns associated with animal-derived compounds and complies with vegan and halal/kosher requirements, broadening its market acceptability.
The global demand for bioactive ingredients in cosmetics and functional foods is rapidly growing. Sialic acid is increasingly incorporated into:
* Anti-aging serums and moisturizers
* Infant formula and follow-on milk
* Functional beverages and health supplements
* Nutritional products for the elderly
With ongoing advancements in synthetic biology and metabolic engineering, the production of Neu5Ac is expected to become even more efficient, further reducing costs and expanding its accessibility. Future research is also exploring its role in antiviral defense, particularly its interaction with pathogens that bind to sialic acid residues.
Sialic acid' s role in hydration, anti-aging, gut health and neurodevelopment makes it a versatile and scientifically proven ingredient. As consumer awareness of bioactive ingredients continues to rise, fermentation-derived sialic acid is becoming a cornerstone for the next generation of cosmeceutical and nutritional formulations!
Privacy Statement
Platform information submission - privacy agreement
● Privacy Policy
We are committed to protecting the privacy, personal data and personal data (collectively referred to as "personal data") provided by you when using this website. Make us comply with the highest standards in terms of collection, use, storage and transmission of personal data (laws and regulations related to privacy of personal data) and consumer protection. To ensure that you have full confidence in the handling of personal data on this website, you must carefully read and understand the provisions of the privacy policy. This website (hereinafter referred to as "us") respects and protects the privacy of users. In particular, once you use this website, you will be deemed to accept, agree, promise and confirm this privacy agreement; You disclose your personal data to us voluntarily with the required consent; You will abide by any modification of this privacy policy; You agree that our relevant business personnel will contact you regarding the products and services you may be interested in (unless you have indicated that you do not want to receive such messages). With your consent, we will collect, manage and monitor the types of personal data collected
1. Scope of application
It is our unremitting pursuit to provide users with better, better and more personalized services. We also hope that the services we provide will be more convenient for your needs. This privacy policy applies to all information collection services provided by this website. You can visit this website and use the services provided by this website using this privacy policy
2. What information do we collect
In order to provide you with our various services, you need to provide personal data information, including personal data and anonymous data, including but not limited to: personal data (your name, gender, age, date of birth, telephone number, fax number, address or mailing address, e-mail address, etc.)
3. How to use the collected information
The purposes and purposes of collecting personal data and anonymous data are as follows: to provide you with our services through this website; When you use our website, you can identify and confirm your identity; Let you get the service for you when you use this website; The relevant business personnel of this website can contact you when necessary; Make it more convenient for you to use this website; The personal data and anonymous data provided by you to us will only be retained until the collection purpose has been achieved, unless they are retained due to applicable laws and regulations. The ownership of personal data and disclosure of all data collected on our website are owned by us and will not be leased or sold to any unrelated third party
4. How do we protect information
For the protection of personal data, we implement appropriate physical, electronic and management measures to protect and guarantee the safety of your personal data. We try our best to ensure that any personal data collected through this website is free from any nuisance of a third party unrelated to us. The security measures we take are not limited to: physical measures: the records with your personal data will be stored in a locked place Electronic measures: the computer data with your personal data will be stored in the computer system and storage media subject to strict login restrictions Management measures: only employees authorized by us can access your personal data, These employees need to comply with our internal rules on the confidentiality of personal data. If you are aware of any security loopholes on this website, please contact us in time so that we can take appropriate actions as soon as possible; Despite the implementation of the above security measures, we cannot guarantee the absolute security of data transmission on the Internet, so we cannot absolutely guarantee that the personal data and anonymous data you provide to us through this website are safe at all times. We will not be responsible for any unauthorized access to your personal data, and we will not be responsible for any losses and damages incurred or caused in this regard.
5. Juvenile Protection Law
The minor has provided personal data to this website without the approval or consent of any parent or guardian. Please contact the public telephone number and customer service telephone number on this website in time to ensure that the data are removed
6. Revision and effectiveness of privacy policy
With the expansion of the service scope of this website, we may revise the Legal Statement and Privacy Policy from time to time, which forms a part of this Legal Statement and Privacy Policy. In order to prevent you from being informed of such revisions, please read this Legal Statement and Privacy Policy frequently. In any way, if you continue to use our services, you agree to be bound by the revised Legal Statement and Privacy Policy
